Compile Data Set for Download or QSAR
maximum 50k data
Found 22 of ic50 data for polymerid = 342,50000603
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50263327(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50263327(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Affinity DataIC50:  59nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50084848(BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50289333(21,35-diazonia-2,13-diazaoctacyclo[33.6.2.214,21.1...)
Affinity DataIC50:  90nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50084852(1,14-diazonia-22,33-diazaheptacyclo[32.6.2.214,21....)
Affinity DataIC50:  110nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50264020(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50:  123nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50084849(Bis-quinolinium cyclophane analogue | CHEMBL258254...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50084839(Bis-quinolinium cyclophane analogue | CHEMBL6266 |...)
Affinity DataIC50:  170nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50084851(Bis-quinolinium cyclophane analogue | CHEMBL266885...)
Affinity DataIC50:  180nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50054105((Z)-1.1'-[stilbene-4,4'-diylbis(methylene)]bis(4-a...)
Affinity DataIC50:  190nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50054098(1,1'-[biphenyl-3,3'-diylbis(methylene)]-bis(4-amin...)
Affinity DataIC50:  290nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50084846(1-[7-(4-amino-1-quinoliniumylmethyl)-9H-2-fluoreny...)
Affinity DataIC50:  310nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50054103(1,1'-[biphenyl-4,4'-diylbis(methylene)]-bis(4-amin...)
Affinity DataIC50:  380nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50054095(1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenethyl]b...)
Affinity DataIC50:  410nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50054096(1-{4-[4-(4-amino-1-quinoliniumylmethyl)benzyl]benz...)
Affinity DataIC50:  450nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50:  530nMAssay Description:Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50264020(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50:  543nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048412(4N-[10-(1-benzyl-4-quinoliniumylamino)decyl]-1-ben...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50275792(CHEMBL452406 | N-benzyl-5-chloropyrazolo[1,5-a]pyr...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50356161(CHEMBL1909931)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of cloned rat SK2 channel expressed in human HEK293 cells by patch clamp assay in the presence of 1 uM intracellular Ca2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of SK2 expressed in CHO FlipIn cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed